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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
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Articles 8 Documents
 1 
Search results for , issue "Vol 40, No 1 (2020)" : 8 Documents clear
The Effect of Quercetin on Plasma Interleukin-5, Blood Eosinophil Absolute, %FEV1, and Clinical Improvement of Asthma Alergy Patient Hesti Nila Mayasari; Suradi Suradi; Ana Rima Setijadi
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.304 KB) | DOI: 10.36497/jri.v40i1.98

Abstract

Backgrounds: Asthma is a chronic airway inflammation which is a manifestation of complex interactions between cells and moleculer mediators. The aims asthma management is to reach asthma in controlled state. Providing an additional therapy in these circumstances is necessary to control asthma. Quercetin as an adjunctive therapy in asthma therapy may improve clinical symptoms and lung function. Methods: Experimental clinical trials of pretest of and postest design were conducted on 34 patient’s asthma at Dr. Moewardi Hospital Surakarta in 6 October–10 December 2018. Subject of treatment group (n= 17) was given quercetin 500 mg per day within 28 days, the control group (n=17) received only standar therapy asthma. Decreased airway inflammation was assessed based on the percentage of blood eosinophil and IL-5. Clinical improvement was assessed by ACT score while lung function used FEV1. Results: Quercetin decreased the inflammatory airways in patients with asthma evidenced by significant decrease in plasma IL-5 of treatment groups but no significant differences between treatment and control group, the mean decrease of blood eosinophil in the treatment group was significant. Querectin improved lung function with decrease FEV1 of treatment groups but no significant differences between treatment and control group and there was a clinical improvement with significant ACT score enhancement in the treatment group. Conclusion: The administration of quercetin significantly reduced inflammation based on decreased levels of eosinophils. There are improvement of lung function and clinical symptoms after quercetin. (J Respir Indo. 2020; 40(1): 16-23)
Differences in the Expression of miRNA-126 and Interleukin (IL)-13 in Fully Controlled and Not Fully Controlled Asthma Patients Yulia Kartina; Susanthy Djajalaksana; Iin Noor Chozin; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i2.99

Abstract

Backgrounds: Important finding in the last decades in the field of biology and medicine are micro-RNA (miRNA), including miRNA-126 that are involved in the regulation of interleukin-13 (IL-13) and the T helper 2 cell (Th2) response, the key components of the asthmatic response. The aim of this study is to find the difference in the expression of miRNA-126 and IL-13 serum in fully controlled and not fully controlled groups of stable asthma patients and analyze the relationship between them. Methods: Case-control studies was conducted in 36 stable asthma patients who visited pulmonary outpatient clinic Saiful Anwar Hospital from September 2018 to March 2019. Subjects were divided into 2 groups, each group consisted of 18 fully controlled asthma and 18 not fully controlled asthma patients. The expression of miRNA-126 was measured by the quantitative polymerase chain reaction (q-PCR) and IL-13 using the enzyme-linked immunosorbent assay (ELISA) method. Results: The expression of miRNA-126 was higher in the control group (3.499±2.99) than case group (2.719±2.73), but the difference was not significant (P=0.273). The IL-13 levels were higher in the case group (17.285±9.37) than control group (11.681±5.22), and the difference was significant (P=0.009). However, there was no relationship between the expression of miRNA-126 and IL-13 levels in both groups. Conclusions: There were differences in IL-13 levels, but there were no differences in the expression of miRNA-126 in the two groups. There was no relationship between miRNA-126 expression and IL-13 levels in both groups. (J Respir Indo. 2020; 40(1): 24-32)
Correlation Between Wood Dust Levels with Interleukin-8 in Blood Serum Wood Processing Workers at X Company, Tanjung Morawa Jubilette Windy Hutabarat; Nuryunita Nainggolan; Amira Permatasari Tarigan; Putri Eyanoer
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i1.94

Abstract

Backgrounds: Wood dust exposure can stimulate proinflammatory cytokines and increase IL-8 levels, which is a foreign body in the body will be phagocytosis by macrophages and excrete mediators such as chemokines, cytokines, and chemoattractants which can cause inflammation. Duration of exposure, number and size of wood dust in the respiratory tract of wood industry workers are associated with various pulmonary disorders such as, COPD, occupational asthma, allergic rhinitis, decreased pulmonary function and pulmonary fibrosis. The aim this study is determine correlation between wood dust levels with interleukin-8 in blood serum among wood processing workers at x company, Tanjung Morawa-North Sumatera. Methods: A cross-sectional study which involved 40 workers from 3 different locations namely cutting, sanding and drafting. Cumulative wood dust exposure was calculated by measuring the dust content at the work site using Dusttrak TSI. IL-8 serum levels were measured using the ELISA technique. The Spearman correlation test was used. Results: Out of 40 workers those who worked in the cutting section were 15 people (37,5%), sanding section were 15 people (37,5%) and drafting section were 10 people (25%). The average level of wood dust PM 2,5 was 5,23 mg/m3while PM10 was 8,24 mg/m3 and the mean level of IL-8 in serum was 163,3 ng/L. This study find that there is a strong correlation between wood dust and IL-8 serum (r = 0,683; p
Climate Caracteristic and Childhood Pneumonia: Systematic Review Anni Fithriyatul Mas’udah; Terry Yuliana Rahadian Pristya
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1229.37 KB) | DOI: 10.36497/jri.v40i1.95

Abstract

Backgrounds: Pneumonia is the leading cause of death in children worldwide. Pneumonia is the cause of mortality in an estimated of 922,000 children under age 5 in 2015, accounting for 15% of all deaths of children under five years old. The climatic conditions are complex and varied, had pneumonia a different impact in each country. The purpose of this study is to address the relationship between complications and childhood pneumonia. Methods: This research was a systematic review of the study literature. The review method follows the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) checklist 2009. The number of articles that match the keywords is 254 articles and 8 articles that can be used. Results: Seven of eight article's differences show the relationship between characteristics and pneumonia in children. Conclusions: There is a relationship with the characteristics of pneumonia in children. (J Respir Indo. 2020; 40(1): 58-65)
The Relationship Between Level of Transforming Growth Factor - β with Pulmonary Fibrosis in Post Pulmonary Tuberculosis in Medan Christine, Tamara; Tarigan, Amira Permatasari; Nainggolan, Nuryunita; Zaluchu, Fotarisman
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i1.90

Abstract

Background: Untreated or undertreated, pulmonary tuberculosis could cause severe complications until death. After treatment, residual lesions might occur. The presence of residual lesions is varied, including: fibrosis, cavity, bronchiectasis and calcification. Transforming growth factor-β (TGF-β) is a cytokine associated with lung inflammation, which plays a role in lung fibrosis. However, only a few studies have assessed the serum level of TGF-β in post-treatment tuberculosis patients. The main objective of this study was to determine the relationship between TGF-β levels and pulmonary fibrosis in patients with pulmonary tuberculosis. Methods: Among 51 patients that had undergone anti-tuberculosis treatment were observed, consisting of 31 men, 20 women. Of all patients, there were 26 people with a smoking history, including 25 men and 1 woman. All patients had been recovered, confirmed by clinical state, laboratory and radiology examination. The ELISA test was performed to measure TGF-β level, while chest X-ray was used to evaluate for the occurence of pulmonary fibrosis. Results: The mean level of TGF-β in patients with lesion (+) was 7628.02 pg/mL (SD: ±4928.38) while the mean level of TGF-β in patients with lesion (-) was 2315.11 pg/mL (SD: ±505.83). Statistical test showed a significant relationship between TGF-β level and fibrosis lesion (P
Lung Diffusion Capacity of X Fighter Pilot in Madiun Ririn Astuty Ningsih; Faisal Yunus; Triya Damayanti; Flora Ekasari; Sita Laksmi Andarini; Dicky Soehardiman; Ratnawati Ratnawati; Fathiyah Isbaniah; Erlang Samoedro
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1007.037 KB) | DOI: 10.36497/jri.v40i1.96

Abstract

Background: Pilot works in the high environment that exposed by G force. Increasing G force led to linear decreases in cardiac output and blood oxygenation of the brain. Thus, likely due to decreased lung gas exchange capacity in hypergravity. This study aims to investigate the pulmonary diffusing capacity test among Fighter pilots in Madiun. Methods: This study used cross sectional method conducted on February 2019 in Madiun. The total subjects consist of 44 Fighter pilots based on total sampling. Interview was done to fill out question about sociodemografic and smoking habit, flight hour data and physical fitness. Lung function measurement was done using portable spirometry and DLCO equipment (Easyone TM Pro Lab). Result: Spirometri result was found in the standard normal range in 41 subjects (93,2%) only 3 subject (6,8%) get obstruction abnormalities and none of them get restriction result. Average VEP1 prediction was 103,3±10,60 % and median range for VEP1/KVP was 84,5(63,5-92,5) %. Lung diffusion capacity measurement was found to be normal in 41 subject (93,2%) and to be deficient in 3 subject (6,8%) in smoker. Conclusion: This study demosntrated that diffusion capacity and spirometry test in Fighter pilots generally in normal range. Lung diffusion capacity has no association with age, BMI, flight hour, physical fitness, Brinkman index and spirometry parameters. (J Respir Indo. 2020; 40(1): 39-47)
Multidrug-Resistant Tuberculosis and Implementation of Control Measures in Ketapang District, West Borneo, Indonesia Imelda Nita Saputri; Eva Lydia Munthe
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.367 KB) | DOI: 10.36497/jri.v40i1.91

Abstract

Background: Multidrug-resistant Tuberculosis (MDR-TB) has emerged as a threat of public health in Indonesia. The utilization of GeneXpert MTB/RIF as a rapid yet effective diagnostic tool enables early and appropriate treatment initiation of MDR-TB. This study aims in describing the occurrence of MDR-TB and the implementation of control measures in Ketapang District, West Borneo, Indonesia, since the utilization of GeneXpert MTB/RIF as a diagnostic tool. Methods: This is a cross-sectional descriptive study. The data were taken from medical record of patients with MDR-TB in Dr.Agoesdjam District General Hospital. The diagnosis was obtained from PCR-based analysis GeneXpert MTB/RIF of sputum sample, which detected Mycobacterium tuberculosis resistant to Rifampicin. Results: Seventeen subjects were included in the study. Subjects were 8 (47%) male and 9 (53%) female aged 24-75 years. Most subjects are farmers (35.3%) or housewives (35.3%), and did not receive formal education (41.2%). The main symptom reported upon admission was cough (41.2%). Direct microscopic smear of sputum detected acid-fast bacilli of +2 (29.4%) and +1 (29.4%) the most. The most common feature seen in thoracic X-ray was infiltrate in 100% of cases. Four subjects (23.5%) have type II diabetes mellitus, while one subject (5.9%) is infected with HIV. Subjects are categorized into new case (17.6%), failure of category 1 treatment (41.2%), and failure of category 2 treatment (41.2%). Treatment for MDR-TB has been initiated since 2014, while two subjects have not started taking the regimen. Among 15 subjects receiving treatment, one (6.7%) was recovered, 6 (40%) subjects deceased, and 8 (53.3%) subjects are currently still taking the regimen, while conversion occurred in 8 (53.3%) subjects. Conclusion: Using the GeneXpert MTB/RIF analysis, 17 cases of MDR-TB have been detected in Ketapang district. Management of MDR-TB has been conducted since 2014.
The Prevalence of Diabetes Mellitus in Chronic Obstructive Pulmonary Disease Patients Mariska Pangaribuan; Faisal Yunus; Triya Damayanti; Rochsismandoko Rochsismandoko
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (742.221 KB) | DOI: 10.36497/jri.v40i1.97

Abstract

Backgrounds: Type 2 diabetes mellitus (DM) is a common comorbidity of COPD. COPD may be considered as a risk factor for new onset type 2 DM via multiple pathophysiological alterations such as systemic inflammation, smoking, oxidative stress, obesity and inhaled corticosteroid use. Exact prevalence of DM in COPD patients in Indonesia still unclear. Co-morbid conditions like DM have great impact on the outcome of COPD in the form of severity, morbidity and mortality. Methods: A cross sectional study was done in Asthma-COPD clinic Persahabatan Hospital from February to March 2017 to screen COPD patients for DM. Sixty-four subjects were recruited. Interview, physical examination and laboratory testing were performed in all subjects. Results: A total of 64 patients with COPD (Males=60, Female=4) with mean age 65±8.7 were screened for DM. Patients with known history of DM were 12 subjects (18.8%) and were enrolled as known DM cases. Remaining 52 subjects (81.3%) whose DM status was unclear were screened by random or fasting blood sugar and HbA1c. Two subjects (3.1%) were considered as newly diagnosed DM cases. Prevalence of DM in present study was 21.9%. Number of patients with pre-diabetes was 16 subjects (25%). There was no significant relationship between gender, age, smoking, nutritional status, airflow limitation and inhaled corticosteroid use in occurrence of DM among COPD patients. Conclusions: Prevalence of DM in COPD patients in the present study is 21.9%. It is important to screen all COPD patients for DM routinely. (J Respir Indo. 2020; 40(1): 48-57)

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